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DiscoverX PathHunter™ CHO-K1 PPYR1 (NPY4R) β-Arrestin Cell Line
The PathHunter™ CHO-K1 PPYR1 (NPY4R) β-Arrestin Cell Line measures PPYR1 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0233C2
This item is not returnable.
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Description
The PathHunter™ PPYR1 (NPY4R) β-Arrestin cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. pancreatic polypeptide) based activation of PPYR1 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged PPYR1 and EA-tagged β-Arrestin 2. Activation of PPYR1 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
β-Arrestin recruitment | |
Cell Lines | |
2 Vials | |
AY268432 |
CHO-K1 | |
Pancreatic polypeptide | |
PPYR1 (NPY4R) |
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