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DiscoverX PathHunter™ CHO-K1 TAAR5 β-Arrestin Orphan GPCR Cell Line
The PathHunter™ CHO-K1 TAAR5 β-Arrestin Orphan GPCR Cell Line measures TAAR5 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0718C2
This item is not returnable.
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Description
The PathHunter™ TAAR5 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. methylamines) based activation of TAAR5 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged TAAR5 and EA-tagged β-Arrestin 2. Activation of TAAR5 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| β-Arrestin recruitment | |
| Cell Lines | |
| TAAR5 |
| CHO-K1 | |
| 2 Vials | |
| NM_003967.2 |
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Product Title
DiscoverX PathHunter™ CHO-K1 TAAR5 β-Arrestin Orphan GPCR Cell Line
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