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DiscoverX PathHunter™ CHRM1 Activated GPCR Internalization U2OS Cell Line
The PathHunter™ CHRM1 Activated GPCR Internalization U2OS Cell Line measures CHRM1 (GPCR) internalization via early-endosome localization. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0655C3
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Description
The PathHunter™ CHRM1 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line enables assessment of ligand (e.g. oxotremorine) based internalization of CHRM1 via detection of localization to the early endosome. This product uses EFC technology. The included cell line overexpresses EA-tagged β-arrestin 2 as well as a PK-tagged early endosome protein and untagged CHRM1. Upon ligand-induced receptor activation, β-arrestin 2 is recruited to the activated GPCR and the resulting CHRM1-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
Receptor Internalization | |
Cell Lines | |
2 Vials | |
AF498915 |
U2OS | |
Acetylcholine | |
CHRM1 |
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DiscoverX PathHunter™ CHRM1 Activated GPCR Internalization U2OS Cell Line
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