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DiscoverX PathHunter™ DDR1 Functional Assay
The PathHunter™ DDR1 Functional Assay measures DDR1 receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0894C3
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Description
The PathHunter™ DDR1 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated DDR1 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged DDR1 and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| Receptor Activation | |
| Cell Lines | |
| 2 Vials | |
| NM_013993.2 |
| U2OS | |
| Bovine Type II Collagen, Immunization Grade | |
| DDR1 |
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DiscoverX PathHunter™ DDR1 Functional Assay
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