missing translation for 'onlineSavingsMsg'
Learn More
Learn More
DiscoverX PathHunter™ FPRL1 Activated GPCR Internalization U2OS Cell Line
The PathHunter™ FPRL1 Activated GPCR Internalization U2OS Cell Line measures FPRL1 (GPCR) internalization via early-endosome localization. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0666C3
This item is not returnable.
View return policy
Description
The PathHunter™ FPRL1 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line enables assessment of ligand (e.g. formylpeptides) based internalization of FPRL1 via detection of localization to the early endosome. This product uses EFC technology. The included cell line overexpresses EA-tagged β-arrestin 2 as well as a PK-tagged early endosome protein and untagged FPRL1. Upon ligand-induced receptor activation, β-arrestin 2 is recruited to the activated GPCR and the resulting FPRL1-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| Receptor Internalization | |
| Cell Lines | |
| 2 Vials | |
| AY225226 |
| U2OS | |
| WKYMVm-NH2 | |
| FPRL1 |
Product Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction