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DiscoverX PathHunter™ HCRTR1 Total GPCR Internalization U2OS Cell Line
The PathHunter™ HCRTR1 Total GPCR Internalization U2OS Cell Line measures HCRTR1 (GPCR) internalization via early-endosome localization. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0729C3
This item is not returnable.
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Description
The PathHunter™ HCRTR1 Total GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line enables assessment of ligand (e.g. orexin A) based internalization of HCRTR1 via detection of localization to the early endosome. This product uses EFC technology. The included cell line overexpresses PK-tagged HCRTR1 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the HCRTR1 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| Receptor Internalization | |
| Cell Lines | |
| 2 Vials | |
| NM_001525.2 |
| U2OS | |
| Orexin A | |
| HCRTR1 |
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