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DiscoverX PathHunter™ HEK 293 PTGER2 β-Arrestin Cell Line
The PathHunter™ HEK 293 PTGER2 β-Arrestin Cell Line measures PTGER2 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0214C1
This item is not returnable.
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Description
The PathHunter™ PTGER2 β-Arrestin cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin E2) based activation of PTGER2 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged PTGER2 and EA-tagged β-Arrestin 2. Activation of PTGER2 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| β-Arrestin recruitment | |
| Cell Lines | |
| 2 Vials | |
| AY275471 |
| 293H | |
| Prostaglandin E2 | |
| PTGER2 |
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