missing translation for 'onlineSavingsMsg'
Learn More
Learn More
DiscoverX PathHunter™ NPY2R Activated GPCR Internalization U2OS Cell Line
The PathHunter™ NPY2R Activated GPCR Internalization U2OS Cell Line measures NPY2R (GPCR) internalization via early-endosome localization. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0721C3
This item is not returnable.
View return policy
Description
The PathHunter™ NPY2R Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line enables assessment of ligand (e.g. peptide YY) based internalization of NPY2R via detection of localization to the early endosome. This product uses EFC technology. The included cell line overexpresses EA-tagged β-arrestin 2 as well as a PK-tagged early endosome protein and untagged NPY2R. Upon ligand-induced receptor activation, β-arrestin 2 is recruited to the activated GPCR and the resulting NPY2R-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| Receptor Internalization | |
| Cell Lines | |
| 2 Vials | |
| AY236540 |
| U2OS | |
| Peptide YY, Human | |
| NPY2R |
Product Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction