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DiscoverX PathHunter™ U2OS C3AR1 β-Arrestin Cell Line
The PathHunter™ U2OS C3AR1 β-Arrestin Cell Line measures C3AR1 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0814C3
This item is not returnable.
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Description
The PathHunter™ C3AR1 β-Arrestin cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. C3a) based activation of C3AR1 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged C3AR1 and EA-tagged β-Arrestin 2. Activation of C3AR1 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| β-Arrestin Recruitment | |
| Cell Lines | |
| 2 Vials | |
| NM_004054.2 |
| U2OS | |
| C3a Receptor Agonist | |
| C3AR1 |
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