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DiscoverX PathHunter™ U2OS ErbB1 Functional Assay
The PathHunter™ U2OS ErbB1 Functional Assay measures ErbB1 receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0863C3
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Description
The PathHunter™ U2OS ErbB1 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated ErbB1 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged ErbB1 and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| SH2 recruitment | |
| Cell Lines | |
| 2 Vials | |
| NM_005228.3 |
| U2OS | |
| Recombinant Human EGF | |
| ErbB1 |
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