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DiscoverX PathHunter™ U2OS GPR85 β-Arrestin Orphan GPCR Cell Line
The PathHunter™ U2OS GPR85 β-Arrestin Orphan GPCR Cell Line measures GPR85 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0409C3
This item is not returnable.
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Description
The PathHunter™ GPR85 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of GPR85 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged GPR85 and EA-tagged β-Arrestin 2. Activation of GPR85 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Orphan receptor with unknown ligand.Specifications
| β-Arrestin recruitment | |
| Cell Lines | |
| GPR85 |
| U2OS | |
| 2 Vials | |
| NM_018970 |
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