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DiscoverX PathHunter™ U2OS mINSRb Functional Assay
The PathHunter™ U2OS mINSRb Functional Assay measures mINSRb receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This cell line ships as two vials of cryopreserved cells. Mouse version.
Brand: DiscoverX 93-1017C3
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Description
The PathHunter™ U2OS mINSRb Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated mINSRb dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged mINSRb and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the mouse version of the protein.Specifications
| SH2 Recruitment | |
| Cell Lines | |
| 2 Vials | |
| AGH68804.1 |
| U2OS | |
| Insulin, Human | |
| mINSRb |
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