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DiscoverX PathHunter™ U2OS TrkB Functional Assay
The PathHunter™ U2OS TrkB Functional Assay measures TrkB receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0463C3
This item is not returnable.
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Description
The PathHunter™ U2OS TrkB Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated TrkB dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged TrkB and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| Receptor Activation | |
| Cell Lines | |
| 2 Vials | |
| NM_006180 |
| U2OS | |
| Recombinant Human BDNF | |
| TrkB |
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