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DiscoverX PathHunter™ U2OS TrkC-P75 Functional Assay
The PathHunter™ U2OS TrkC-P75 Functional Assay measures TrkC-P75 receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0531C3
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Description
The PathHunter™ U2OS TrkC-P75 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated TrkC and P75 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged TrkC and an EA-tagged SH2 domain protein. It also overexpresses an untagged coreceptor, P75 Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
Receptor Activation | |
Cell Lines | |
2 Vials | |
NM_001012338 |
U2OS | |
Recombinant Human NT-3 | |
TrkC-P75 |
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DiscoverX PathHunter™ U2OS TrkC-P75 Functional Assay
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