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DiscoverX PathHunter™ U2OS TSHR (Long Isoform) β-Arrestin Cell Line
The PathHunter™ U2OS TSHR (Long Isoform) β-Arrestin Cell Line measures TSHR(L) (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0760C3
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Description
The PathHunter™ TSHR(L) β-Arrestin cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. TSH) based activation of TSHR GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged TSHR and EA-tagged β-Arrestin 2. Activation of TSHR stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
β-Arrestin Recruitment | |
Cell Lines | |
2 Vials | |
NM_000369.2 |
U2OS | |
TSH, Thyroid stimulating hormone, Human | |
TSHR(L) |
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