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DiscoverX Ready-to-Assay™ β2 Adrenergic Receptor Frozen Cells
The Ready-to-Assay™ β2 Adrenergic Receptor Frozen Cells measure ADRB2 (GPCR) activation via an increase in intracellular calcium. Ready-to-Assay kits contain two vials of thaw-and-use cells.
Brand: DiscoverX HTS073RTA
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Description
The Ready-to-Assay™ β2 Adrenergic Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. epinephrine and norepinephrine) based activation of ADRB2 GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress ADRB2 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of ADRB2 , the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the cells in a convenient thaw-and-use format.Specifications
| β2 | |
| epinephrine and norepinephrine | |
| ADRB2 |
| Frozen Cells | |
| 2 Vials of Cells |
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DiscoverX Ready-to-Assay™ β2 Adrenergic Receptor Frozen Cells
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