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DiscoverX Ready-to-Assay™ 5-HT2A Serotonin Receptor Frozen Cells
The Ready-to-Assay™ 5-HT2A Serotonin Receptor Frozen Cells measure HTR2A (GPCR) activation via an increase in intracellular calcium. Ready-to-Assay kits contain two vials of thaw-and-use cells.
Brand: DiscoverX HTS082RTA
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Description
The Ready-to-Assay™ 5-HT2A Serotonin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. serotonin/5-HT) based activation of HTR2A GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress HTR2A alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of HTR2A , the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the cells in a convenient thaw-and-use format.Specifications
| 5-HT2A | |
| serotonin/5-HT | |
| HTR2A |
| Frozen Cells | |
| 2 Vials of Cells |
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