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DiscoverX Ready-to-Assay™ FP Prostanoid Receptor Frozen Cells
The Ready-to-Assay™ FP Prostanoid Receptor Frozen Cells measure PTGFR (GPCR) activation via an increase in intracellular calcium. Ready-to-Assay kits contain two vials of thaw-and-use cells.
Brand: DiscoverX HTS093LRTA
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Description
The Ready-to-Assay™ FP Prostanoid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. prostaglandin F2a) based activation of PTGFR GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress PTGFR alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of PTGFR , the resulting calcium activity can be assayed in either detection mode. Ready-to-assay kits consist of two vials of the cells in a convenient thaw-and-use format.Specifications
| FP | |
| prostaglandin F2a | |
| PTGFR |
| Frozen Cells | |
| 2 Vials of Cells |
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