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DiscoverX Ready-to-Assay™ GLP-1 Receptor Frozen Cells
The Ready-to-Assay™ GLP-1 Receptor Frozen Cells measure GLP1R (GPCR) activation via an increase in intracellular calcium. Ready-to-Assay kits contain two vials of thaw-and-use cells.
Brand: DiscoverX HTS163LRTA
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Description
The Ready-to-Assay™ GLP-1 Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. GLP-1) based activation of GLP1R GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress GLP1R alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of GLP1R , the resulting calcium activity can be assayed in either detection mode. Ready-to-assay kits consist of two vials of the cells in a convenient thaw-and-use format.Specifications
| GLP-1 | |
| GLP-1 | |
| GLP1R |
| Frozen Cells | |
| 2 Vials of Cells |
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DiscoverX Ready-to-Assay™ GLP-1 Receptor Frozen Cells
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