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DiscoverX Ready-to-Assay™ XCR1 Chemokine Receptor Frozen Cells
The Ready-to-Assay™ XCR1 Chemokine Receptor Frozen Cells measure XCR1 (GPCR) activation via an increase in intracellular calcium. Ready-to-Assay kits contain two vials of thaw-and-use cells.
Brand: DiscoverX HTS053RTA
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Description
The Ready-to-Assay™ XCR1 Chemokine Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. lymphotactin) based activation of XCR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress XCR1 alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of XCR1 , the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the cells in a convenient thaw-and-use format.Specifications
| XCR1 | |
| lymphotactin | |
| XCR1 |
| Frozen Cells | |
| 2 Vials of Cells |
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