missing translation for 'onlineSavingsMsg'
Learn More
Learn More
STEMCELL Technologies Tamoxifen
Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor
Brand: STEMCELL Technologies 72666
This item is not returnable.
View return policy
Description
- Tamoxifen is a selective estrogen receptor modulator (SERM), with tissue-specific antagonistic or agonistic effects
- Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription
- Tamoxifen is commonly used to activate Cre-ER in transgenic conditional models
- Used in transgenic models to induce Cre-mediated recombination in conjunction with Cre-ER, a fusion protein consisting of Cre recombinase and a mutant form of the estrogen receptor hormone-binding domain that specifically binds tamoxifen but not estrogen (Feil et al.; Zhang et al.)
- Inhibits growth in the human breast cancer cell line, MCF-7 (Katzenellenbogen et al.)
- Antagonist of estrogen receptor action in breast tissue and breast cancer cells (Abe et al.; Horwitz et al.)
Specifications
| 10540-29-1 | |
| 10 g | |
| ≥95% |
| trans-Tamoxifen | |
| C26H29NO |
Product Suggestions
Customers who viewed this item also viewed
Viewing 1-4 of
Product Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Product Title
STEMCELL Technologies Tamoxifen
Spot an opportunity for improvement?Share a Content Correction
