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Tocris Bioscience™ VH 298

High-affinity inhibitor of VHL

Brand: Tocris Bioscience™ 6156/10

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Product Code. 18721378

336.00€ / 10mg

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Estimated Shipment: 29-01-2025
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Description

VH 298 is a high-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response. Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes, with similar transcriptional profile to hypoxia. Cell permeable.

Negative control cis VH 298 also available.

Specifications

Product Type	Inhibitor
Molecular Formula	C₂₇H₃₃N₅O₄S
Content And Storage	Store at -20°C
Quantity	10 mg

Target Proteins	Ubiquitin Ligase (E3)
Formula Weight	523.65g/mol
For Use With (Application)	Ubiquitin Ligase (E3) Inhibitors

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Tocris Bioscience™ VH 298

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