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Tocris Bioscience™ VH 298
High-affinity inhibitor of VHL
336.00€ - 1335.00€
Specifications
Product Type | Inhibitor |
---|---|
Target Proteins | Ubiquitin Ligase (E3) |
Molecular Formula | C27H33N5O4S |
Formula Weight | 523.65g/mol |
Content And Storage | Store at -20°C |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
18721378
|
Tocris Bioscience™
6156/10 |
10 mg |
336.00€
10mg |
Estimated Shipment: 29-01-2025
Log in to see stock. |
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18770268
|
Tocris Bioscience™
6156/50 |
50 mg |
1335.00€
50mg |
Estimated Shipment: 29-01-2025
Log in to see stock. |
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Description
High-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response. Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes, with similar transcriptional profile to hypoxia. Cell permeable.Negative control cis VH 298 also available.
Specifications
Inhibitor | |
C27H33N5O4S | |
Store at -20°C |
Ubiquitin Ligase (E3) | |
523.65g/mol | |
Ubiquitin Ligase (E3) Inhibitors |
For Research Use Only
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