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Tocris Bioscience™ VH 298
High-affinity inhibitor of VHL
Brand: Tocris Bioscience™ 6156/10
257.45 EUR valid until 2024-12-16
Use promo code "21630" to get your promotional price.
This item is not returnable.
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Description
VH 298 is a high-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response. Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes, with similar transcriptional profile to hypoxia. Cell permeable.Negative control cis VH 298 also available.
Specifications
| Inhibitor | |
| C27H33N5O4S | |
| Store at -20°C | |
| 10 mg |
| Ubiquitin Ligase (E3) | |
| 523.65g/mol | |
| Ubiquitin Ligase (E3) Inhibitors |
For Research Use Only